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Participación en actividades de estimulación cognitiva y riesgo de enfermedad de Alzheimer incidente

Robert S Wilson¹, Carlos F Mendes De Leon, Lisa L Barnes

¹Rush Alzheimer's Disease Center, 1645 W Jackson Blvd, Suite 675, Chicago, IL 60612, USA. rwilson@rush.edu

|February 20, 2002

Resumen

Participar en actividades mentalmente estimulantes puede reducir el riesgo de enfermedad de Alzheimer (EA). Este estudio encontró que la actividad cognitiva frecuente estaba relacionada con una reducción del 33% en el riesgo de desarrollar AD.

Área de la Ciencia:

La neurociencia es la neurociencia.
Gerontología Gerontología.
Salud Pública La salud pública.

Sus antecedentes:

Se supone que las actividades estimulantes cognitivas reducen el riesgo de enfermedad de Alzheimer (EA).
Los datos prospectivos sobre esta asociación han sido limitados.

Objetivo del estudio:

Investigar la asociación entre la participación frecuente en actividades cognitivas y el riesgo de desarrollar AD.
Para probar la hipótesis de que una mayor actividad cognitiva es protectora contra la enfermedad de Alzheimer.

Principales métodos:

Estudio longitudinal de cohorte de 801 monjas, sacerdotes y hermanos católicos mayores sin demencia.
La frecuencia de actividad cognitiva basal se midió utilizando una puntuación compuesta validada.
Los participantes fueron seguidos durante un promedio de 4,5 años para el diagnóstico de EA y los cambios en la función cognitiva.

Principales resultados:

Un aumento de 1 punto en la puntuación de actividad cognitiva se asoció con una reducción del 33% en el riesgo de EA (HR, 0.67).
Esta asociación se mantuvo significativa después de ajustar por edad, sexo, educación y otros factores.
El aumento de la actividad cognitiva también se correlacionó con una disminución en la cognición global, la memoria de trabajo y la velocidad perceptiva.

Conclusiones:

La participación frecuente en actividades estimulantes cognitivas se asocia con un riesgo reducido de enfermedad de Alzheimer.
Promover el compromiso cognitivo puede ser una estrategia viable para la prevención de la enfermedad de Alzheimer.

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