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El gen alfa del receptor activado por el proliferador de peroxisomas regula el crecimiento del ventrículo izquierdo
Yalda Jamshidi1, Hugh E Montgomery, Hans-Werner Hense
1Centre for Cardiovascular Genetics, Department of Medicine, University College London Medical School, London, UK.
Circulation
|February 28, 2002
Resumen
La variación genética en el gen del receptor alfa activado por el proliferador peroxisomático (PPARalpha) influye en el crecimiento ventricular izquierdo en respuesta al ejercicio y la hipertensión, lo que afecta el desarrollo de la hipertrofia ventricular izquierda (LVH).
Área de la Ciencia:
- Fisiología cardiovascular fisiología cardiovascular.
- Genética molecular La genética molecular.
- Fisiología Humana Fisiología Humana.
Sus antecedentes:
- La hipertrofia ventricular izquierda (LVH) es una respuesta adaptativa al aumento de la carga de trabajo cardíaca, pero sus mecanismos moleculares siguen sin estar claros.
- Los defectos hereditarios en la oxidación de los ácidos grasos están relacionados con la hipertrofia cardíaca de inicio temprano.
- El receptor alfa activado por el proliferador de peroxisomas (PPARalpha) regula la oxidación de los ácidos grasos del miocardio y se regula a la baja durante la hipertrofia cardíaca.
Objetivo del estudio:
- Para investigar el papel de la variación del gen PPARalpha en el crecimiento del ventrículo izquierdo humano.
- Para determinar si PPARalpha influye en la LVH en respuesta al ejercicio y la hipertensión.
Principales métodos:
- Examinó a 144 reclutas masculinos del Ejército Británico sometidos a entrenamiento físico.
- Se analizaron datos ecocardiográficos de 1148 participantes en el estudio MONICA Augsburg.
- Se evaluó el impacto de un polimorfismo G / C en el intrón 7 del gen PPARalpha en la masa ventricular izquierda (LV).
Principales resultados:
- Un polimorfismo G / C en el gen PPARalpha influyó significativamente en el crecimiento de LV en respuesta al ejercicio (P = 0,009).
- Los individuos con el alelo C mostraron mayores aumentos en la masa LV en comparación con los homocigotos del alelo G.
- Los homocigotos del alelo C exhibieron una mayor masa de LV y una mayor prevalencia de LVH, particularmente en sujetos hipertensos.
Conclusiones:
- La variación en el gen PPARalpha afecta el crecimiento ventricular izquierdo humano debido al ejercicio y la hipertensión.
- La utilización inadecuada del sustrato cardíaco, influenciada por PPARalpha, puede contribuir a la patogénesis de la HLV.
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