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Terapia de reemplazo hormonal y prevención de úlceras por presión y úlceras venosas en las piernas
Lancet (London, England)
|March 7, 2002
Resumen
La terapia de reemplazo hormonal (TRH) puede prevenir heridas crónicas como úlceras por presión y úlceras venosas en las piernas. Los pacientes de edad avanzada que usaban TRH mostraron una incidencia significativamente menor de desarrollar estas afecciones comunes y debilitantes.
Área de la Ciencia:
- Gerontología Gerontología.
- Dermatología Dermatología dermatología.
- Endocrinología Endocrinología.
Sus antecedentes:
- Las úlceras por presión y las úlceras venosas en las piernas son heridas crónicas prevalentes en las poblaciones de ancianos.
- El papel potencial de los estrógenos, particularmente a través de la terapia de reemplazo hormonal (TRH), en la cicatrización de heridas sigue siendo poco investigado.
Objetivo del estudio:
- Investigar la asociación entre el uso de TRH y la incidencia de úlceras venosas en las piernas y úlceras por presión en pacientes ancianos.
Principales métodos:
- Se empleó un diseño de estudio de caso-cohorte.
- Los datos se obtuvieron de la Base de Datos de Investigación de Práctica General del Reino Unido, incluida una gran cohorte de pacientes ancianos.
- Se compararon las tasas de incidencia de heridas crónicas específicas entre usuarios y no usuarios de TRH.
Principales resultados:
- Los pacientes que recibieron TRH demostraron una probabilidad significativamente reducida de desarrollar úlceras venosas en las piernas (riesgo relativo ajustado por edad 0,65 [95% IC 0,61-0,69]).
- Del mismo modo, las usuarias de TRH mostraron una menor incidencia de úlceras de presión (riesgo relativo ajustado por edad 0,68 [95% IC 0,62-0,76]).
Conclusiones:
- La terapia de reemplazo hormonal puede ofrecer un efecto protector contra el desarrollo de heridas crónicas comunes.
- La TRH podría ser una estrategia preventiva beneficiosa para las úlceras de presión y las úlceras venosas de las piernas en los ancianos.
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