Video Experimental Relacionado
Updated: Jul 11, 2026
08:51
Evaluation of Mammary Gland Development and Function in Mouse Models
Published on: July 21, 2011
Desarrollo hipofisario: códigos regulatorios en la organogénesis de mamíferos
Kathleen M Scully1, Michael G Rosenfeld
1Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, 9500 Gilman Drive, Room 345, La Jolla, CA 92093, USA.
Science (New York, N.Y.)
|March 23, 2002
Resumen
El desarrollo de la glándula pituitaria de los mamíferos implica gradientes de señalización que activan los reguladores transcripcionales. Estos factores controlan la proliferación y diferenciación celular, permitiendo flexibilidad en la identidad celular.
Área de la Ciencia:
- Biología del desarrollo Biología del desarrollo.
- Endocrinología Endocrinología.
- Biología Molecular Biología Molecular
Sus antecedentes:
- El desarrollo de la glándula pituitaria de los mamíferos se origina en un primordial común.
- Los tipos específicos de células surgen debido a los gradientes de señalización opuestos de los centros organizadores.
Objetivo del estudio:
- Para dilucidar los mecanismos moleculares que rigen la especificación del tipo de célula pituitaria.
- Comprender el papel de los reguladores de la transcripción en la proliferación y diferenciación de las células precursoras.
Principales métodos:
- Análisis de los patrones de expresión génica durante el desarrollo de la hipófisis.
- Investigando la interacción de los activadores de unión al ADN y los transrepresores.
- Estudiar el reclutamiento de complejos correguladores para la regulación génica.
Principales resultados:
- Los gradientes de señalización inducen reguladores transcripcionales que interactúan en patrones superpuestos.
- Estos reguladores controlan sinérgicamente la proliferación de precursores y la inducción del tipo celular.
- La diferenciación terminal implica la activación selectiva de genes y su represión sostenida.
Conclusiones:
- Una compleja regulación transcripcional gobierna el destino de las células pituitarias.
- Los mecanismos permiten la plasticidad en la identidad final de las células pituitarias diferenciadas.
Videos de Conceptos Relacionados
01:51Determination
During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...
01:27Growth of Cartilage and Bone Tissue
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
01:17Hormones and Bone Tissue
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
01:09Changes in the Appendicular Skeleton with Age
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
01:12The Mammary Glands
The female breast is a hemispheric projection of variable size positioned anterior to the pectoralis major and serratus anterior muscles. A fascia layer composed of dense, irregular connective tissue connects it to these muscles.
Each breast features a pigmented projection known as the nipple, through which milk emerges via closely spaced openings of ducts, referred to as lactiferous ducts. Surrounding the nipple is a circular pigmented area of skin named the areola, which appears rough due to...
Each breast features a pigmented projection known as the nipple, through which milk emerges via closely spaced openings of ducts, referred to as lactiferous ducts. Surrounding the nipple is a circular pigmented area of skin named the areola, which appears rough due to...
01:15Development of the Sexual Organs in the Embryo and Fetus
Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the male...
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the male...