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Sensor neuronal de calcio 1 y facilitación dependiente de la actividad de las corrientes de calcio tipo P/Q en los
Tetsuhiro Tsujimoto1, Andreas Jeromin, Naoto Saitoh
1Department of Neurophysiology, University of Tokyo Faculty of Medicine, Tokyo 113-0033, Japan. tujimoto-tky@umin.ac.jp
Science (New York, N.Y.)
|March 23, 2002
Resumen
El sensor neuronal de calcio 1 (NCS-1) facilita las corrientes de calcio tipo P/Q (IpCa) en las terminales nerviosas. El calcio residual activa NCS-1, mejorando la transmisión sináptica y potencialmente impactando muchas sinapsis.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Biología Molecular Biología Molecular
- Fisiología Sináptica Fisiología Sináptica
Sus antecedentes:
- Las corrientes presinápticas de calcio tipo P/Q (IpCa) muestran una facilitación dependiente de la actividad en el cáliz de la sinapsis Held.
- Los mecanismos moleculares que subyacen a esta facilitación sináptica no se comprenden completamente.
Objetivo del estudio:
- Investigar el papel del sensor neuronal de calcio 1 (NCS-1) en la facilitación dependiente de la actividad de las corrientes de calcio tipo P/Q.
- Para determinar si NCS-1 media los efectos del calcio residual en la transmisión sináptica.
Principales métodos:
- Carga directa del NCS-1 en las terminales nerviosas.
- Carga presináptica de un péptido carboxilo-terminal de NCS-1 en el cuerpo.
- Registros electrofisiológicos de las corrientes de calcio tipo P/Q (IpCa).
Principales resultados:
- La carga directa de NCS-1 imitaba la facilitación IpCa dependiente de la actividad.
- NCS-1 aceleró la activación de IpCa de una manera dependiente del Ca2+.
- Un péptido presináptico NCS-1 abolió la facilitación de IpCa, lo que sugiere que el Ca2+ residual activa el NCS-1 endógeno.
Conclusiones:
- NCS-1 juega un papel crucial en la facilitación dependiente de la actividad de las corrientes de calcio tipo P/Q.
- Es probable que el calcio residual active el NCS-1, lo que lleva a una mejor transmisión sináptica.
- NCS-1 puede contribuir a la facilitación sináptica en numerosas sinapsis de mamíferos debido a su amplia expresión.
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