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Olfaction01:25

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...

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Video Experimental Relacionado

Updated: Jun 30, 2026

Imaging Pheromone Sensing in a Mouse Vomeronasal Acute Tissue Slice Preparation
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Imaging Pheromone Sensing in a Mouse Vomeronasal Acute Tissue Slice Preparation

Published on: December 6, 2011

Las feromonas, la función vomeronasal y el comportamiento específico de género.

Eric B Keverne1

  • 1Sub-Department of Animal Behaviour, University of Cambridge, Madingley, CB3 8AA, Cambridge, United Kingdom. ebk10@cus.cam.ac.uk

Cell
|April 17, 2002
PubMed
Resumen
Este resumen es generado por máquina.

Los ratones sin el canal iónico TRP2 muestran comportamientos distintos, revelando el papel crucial del órgano vomeronasal en las interacciones sociales y la reproducción específicas del sexo.

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Área de la Ciencia:

  • La neurociencia es la neurociencia.
  • Biología del comportamiento Biología del comportamiento.
  • Los sistemas sensoriales son sistemas sensoriales.

Sus antecedentes:

  • El órgano vomeronasal (VNO) es una estructura sensorial implicada en la detección de feromonas.
  • Los canales iónicos TRP2 se expresan en el VNO y son cruciales para la transducción sensorial.

Objetivo del estudio:

  • Para investigar el papel del canal iónico TRP2 en la función del órgano vomeronasal.
  • Para aclarar la contribución de la VNO y TRP2 a los comportamientos sexuales específicos de género en ratones.

Principales métodos:

  • Análisis del comportamiento de ratones que carecen del canal iónico TRP2 (ratones knockout TRP2).
  • Evaluación de los comportamientos sociales y sexuales en entornos experimentales controlados.

Principales resultados:

  • Los ratones knockout TRP2 exhiben comportamientos sexuales específicos de género significativamente alterados en comparación con los controles de tipo salvaje.
  • Estos déficits conductuales resaltan el papel crítico de la entrada sensorial mediada por VNO en la regulación de los comportamientos reproductivos.

Conclusiones:

  • El canal iónico TRP2 es esencial para la función normal del órgano vomeronasal.
  • La señalización del órgano vomeronasal, mediada por TRP2, es indispensable para la ejecución precisa de comportamientos sexuales específicos de género.