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Estructura de un complejo HIF-1alfa-pVHL: reconocimiento de hidroxiprolina en la señalización

Jung-Hyun Min1, Haifeng Yang, Mircea Ivan

  • 1Cellular Biochemistry and Biophysics Program and Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

Science (New York, N.Y.)
|May 11, 2002
PubMed
Resumen

El supresor de tumores de von Hippel-Lindau (pVHL) se une al factor inducible por hipoxia hidroxilado (HIF) a través de la hidroxiprolina, crucial para la detección de oxígeno y la respuesta celular. Esta interacción es esta interacción.

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