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Síntesis quimioenzimática eficiente de los oligosacáridos de sialilo vinculados por O

Ola Blixt1, Kirk Allin, Laura Pereira

  • 1The Scripps Research Institute, Department of Molecular Biology, MEM-L71, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Journal of the American Chemical Society
|May 16, 2002
PubMed
Resumen

Un nuevo método quimioenzimático sintetiza de manera eficiente los antígenos T y Tn sializados, biomarcadores cruciales del cáncer. Este enfoque utiliza sialyltransferases recombinantes para la síntesis a escala preparatoria de glicanos complejos enlazados con O.

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