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Modulación mediada por dopamina de los potenciales de la amígdala evocados por el olor durante el acondicionamiento

J Amiel Rosenkranz¹, Anthony A Grace

¹Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA. rosenk@bns.pitt.edu

|May 17, 2002

Resumen

El acondicionamiento pavloviano mejora las respuestas neuronales en el núcleo lateral de la amígdala (LAT). La dopamina es crucial para esta formación de la memoria emocional, influyendo en la excitabilidad neuronal y la plasticidad sináptica.

Área de la Ciencia:

La neurociencia es la neurociencia.
Ciencias del comportamiento Ciencias del comportamiento.
La neurobiología es la neurobiología.

Sus antecedentes:

El condicionamiento pavloviano implica asociar un estímulo neutro con uno relevante, lo que lleva a respuestas aprendidas.
El núcleo lateral de la amígdala (LAT) es crítico para la formación de la memoria emocional durante el acondicionamiento.
La actividad neuronal en LAT aumenta con el acondicionamiento y es modulada por la dopamina.

Objetivo del estudio:

Investigar cambios en la excitabilidad neuronal y el impulso sináptico en LAT durante el condicionamiento pavloviano.
Para aclarar el papel de la dopamina en estos cambios neurofisiológicos.

Principales métodos:

Se realizaron grabaciones intracelulares in vivo en neuronas LAT en ratas durante el acondicionamiento pavloviano.
Las ratas fueron expuestas a olores emparejados o no emparejados y estímulos de foot-shock.
El antagonista de la dopamina haloperidol fue administrado para evaluar el papel de la dopamina.

Principales resultados:

El acondicionamiento pareado de olor-pie-shock mejoró las respuestas de potencial postsináptico (PSP) y la excitabilidad neuronal en las neuronas LAT.
Un olor no emparejado condujo a una disminución en las respuestas de PSP, lo que indica un hábito.
El haloperidol bloqueó la mejora de la PSP y aumentó la excitabilidad, pero no revirtió el acondicionamiento establecido.

Conclusiones:

El acondicionamiento y la habituación inducen efectos opuestos en la actividad neuronal LAT.
La dopamina juega un papel vital en la mediación de los cambios neurofisiológicos asociados con la formación de la memoria emocional en LAT.
Estos hallazgos apoyan el papel establecido de la dopamina en los procesos de memoria emocional.

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