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Updated: Jun 24, 2026

Locked Nucleic Acid Flow Cytometry-fluorescence in situ Hybridization (LNA flow-FISH): a Method for Bacterial Small RNA Detection
09:45

Locked Nucleic Acid Flow Cytometry-fluorescence in situ Hybridization (LNA flow-FISH): a Method for Bacterial Small RNA Detection

Published on: January 10, 2012

Reconocimiento de ácido nucleico bloqueado (LNA) de las estructuras de la solución de ARN: RMN de los híbridos LNA:

Michael Petersen1, Kent Bondensgaard, Jesper Wengel

  • 1Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Odense University, DK-5230 Odense M, Denmark. mip@chem.sdu.dk

Journal of the American Chemical Society
|May 23, 2002
PubMed
Resumen

Los ácidos nucleicos bloqueados (LNA) mejoran la estabilidad híbrida de ADN: ARN y alteran la estructura dúplex. La incorporación de tres monómeros LNA cambia la geometría hacia un dúplex de tipo A, alcanzando la saturación para los cambios estructurales.

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