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Cingulado anterior: señales neuronales individuales relacionadas con el grado de expectativa de recompensa
Munetaka Shidara1, Barry J Richmond
1Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology, 1-1-1 Umezono, Tsukuba, Ibaraki 305-8568, Japan. m.shidara@aist.go.jp
Science (New York, N.Y.)
|June 1, 2002
Resumen
Los monos muestran una mayor motivación a medida que se acercan las recompensas, con las neuronas de la corteza cingulada anterior que reflejan esta expectativa de recompensa cambiante. Esta actividad neuronal puede verse alterada en condiciones como el trastorno obsesivo-compulsivo y el abuso de drogas.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- La economía del comportamiento es la economía del comportamiento.
Sus antecedentes:
- Los monos que realizan programas de recompensas exhiben tasas de error decrecientes a medida que se acercan las recompensas.
- Este cambio de comportamiento sugiere un aumento de la motivación y / o la expectativa de recompensa.
Objetivo del estudio:
- Investigar correlatos neuronales del cambio de la expectativa de recompensa en la corteza cingulada anterior (ACC).
- Explorar el papel de la actividad del ACC en condiciones de procesamiento alterado de la recompensa.
Principales métodos:
- Grabaciones de una sola neurona en el ACC de monos durante el desempeño de los programas de recompensa.
- Análisis de las respuestas neuronales relativas a las señales de proximidad y expectativas de recompensa.
Principales resultados:
- Aproximadamente un tercio de las neuronas ACC registradas mostraron respuestas que cambiaban progresivamente con la expectativa de recompensa.
- Esta respuesta neuronal progresiva desapareció cuando las señales de recompensa fueron aleatorizadas.
- Se observaron cambios en la progresión neural en relación con la expectativa de recompensa.
Conclusiones:
- La actividad neuronal del ACC rastrea dinámicamente la expectativa de recompensa durante el desempeño de la tarea.
- Las progresiones neurales aberrantes del ACC pueden ser la base de los trastornos del procesamiento de la recompensa en el trastorno obsesivo-compulsivo y el abuso de drogas.
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