Video Experimental Relacionado

Updated: Jul 12, 2026

In vivo Near Infrared Fluorescence (NIRF) Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis

In vivo Near Infrared Fluorescence (NIRF) Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis

Published on: August 4, 2011

Imagen de la inflamación de la placa aterosclerótica con tomografía por emisión de positrones de

J H F Rudd¹, E A Warburton, T D Fryer

¹Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.

|June 12, 2002

Resumen

Las imágenes de 18F-fluorodeoxiglucosa (18FDG)-PET pueden identificar la inflamación en las placas ateroscleróticas. Las placas carotídicas sintomáticas mostraron una mayor absorción de 18FDG, lo que indica un aumento de la inflamación en comparación con las lesiones asintomáticas.

Área de la Ciencia:

Imágenes cardiovasculares por imágenes.
La medicina nuclear es una medicina nuclear.
Imágenes moleculares de imágenes.

Sus antecedentes:

La ruptura de la placa aterosclerótica está relacionada con la inflamación.
Las imágenes actuales carecen de una evaluación de la inflamación de la placa.
18F-fluorodeoxiglucosa (18FDG) PET visualiza la actividad de las células inflamatorias.

Objetivo del estudio:

Para evaluar 18FDG-PET para imágenes de la inflamación de la placa aterosclerótica de la arteria carótida.
Para comparar la absorción de 18FDG en placas sintomáticas frente a las asintomáticas.

Principales métodos:

Ocho pacientes con aterosclerosis carotídea sintomática se sometieron a 18FDG-PET y tomografías computarizadas.
La absorción de 18FDG se midió 3 horas después de la inyección.
La autoradiografía confirmó la acumulación de desoxiglucosa en los macrófagos.

Principales resultados:

Las placas carotídicas sintomáticas se visualizaron a través de 18FDG-PET.
La acumulación de 18FDG fue un 27% más alta en las placas sintomáticas que en las asintomáticas.
Las arterias carótidas normales no mostraron absorción medible de 18FDG.

Conclusiones:

18FDG-PET ha obtenido con éxito imágenes de la inflamación de la placa aterosclerótica.
Las placas sintomáticas e inestables exhiben una mayor acumulación de 18FDG.

Más Videos Relacionados

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT)

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT)

Published on: May 2, 2012

PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke

PET Imaging of Neuroinflammation Using [¹¹C]DPA-713 in a Mouse Model of Ischemic Stroke

Published on: June 14, 2018

Videos de Conceptos Relacionados

Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...