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Updated: Jul 10, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
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Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase

Published on: November 23, 2016

Fapy.dG instruye a Klenow exo(-) para que incorpore erróneamente la desoxyadenosina

Carissa J Wiederholt1, Marc M Greenberg

  • 1Department of Chemistry, Colorado State University, Ft. Collins, Colorado 80523, USA.

Journal of the American Chemical Society
|June 20, 2002
PubMed
Resumen

N-(2-deoxy-alfa,beta-d-erythropentofuranosyl) -N-(2,6-diamino-4-hydroxy-5-formamidopyrimidine) (Fapy.dG) aumenta significativamente los errores de replicación del ADN por Klenow exo-. significativamente aumenta los errores de replicación del ADN por Klenow exo. también por Klenow. Esta lesión causa una incorporación errónea frecuente y una extensión ineficiente, lo que lleva a una tasa de error 80 millones de veces mayor.

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