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El control traslacional del ciclo celular embrionario
Irina Groisman1, Mi-Young Jung, Madathia Sarkissian
1Program in Molecular Medicine, University of Massachusetts Medical School, Worcester 01605, USA.
Cell
|June 28, 2002
Resumen
La traducción regulada del ARNm de ciclina B1, controlada por poliadenilación, es esencial para el ciclo celular embrionario. Este mecanismo, que involucra a CPEB y Maskin, puede ser una característica general de la mitosis en las células animales.
Área de la Ciencia:
- Biología celular Biología celular.
- Biología Molecular Biología Molecular
- Biología del desarrollo Biología del desarrollo.
Sus antecedentes:
- La mitosis en las células eucariotas es impulsada por la síntesis y degradación de la ciclina B.
- La progresión del ciclo celular también está influenciada por la traducción de la ciclina B.
- La traducción del ARNm de la ciclina B1 está regulada durante el ciclo celular.
Objetivo del estudio:
- Para investigar el papel de la traducción del ARNm ciclina B1 en el ciclo celular embrionario.
- Aclarar los mecanismos que regulan la traducción del ARNm de la ciclina B1.
- Determinar si el control traslacional por poliadenilación es una característica general de la mitosis.
Principales métodos:
- Estudió extractos ciclistas de embriones de Xenopus.
- Investigó el papel de la poliadenilación y la deadenilación en la regulación del ARNm de la ciclina B1.
- Examinó la participación de CPEB, Aurora quinasa y Maskin en el control traslacional.
Principales resultados:
- La progresión a la fase M requiere una traducción inducida por poliadenilación del ARNm de ciclina B1.
- La fosforilación de CPEB por la aurora quinasa media en la poliadenilación.
- La salida de la fase M implica la deadenilación y el silenciamiento traslacional del ARNm ciclina B1 por Maskin.
- La expresión de Maskin está regulada por el ciclo celular.
Conclusiones:
- La traducción regulada del ARNm de ciclina B1 es esencial para el ciclo celular embrionario.
- La traducción del ARNm de la ciclina B1 está controlada por la poliadenilación y la deadenilación.
- La poliadenilación citoplasmática dependiente del ciclo celular en las células de mamíferos sugiere que esta es una característica mitótica general en las células animales.
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