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La adiponectina y el desarrollo de la diabetes tipo 2 en la población india Pima
Robert S Lindsay1, Tohru Funahashi, Robert L Hanson
1National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 1550 East Indian School Road, Phoenix, AZ 85014, USA. rlindsay@mail.nih.gov
Lancet (London, England)
|July 13, 2002
Resumen
Los niveles más bajos de adiponectina, una proteína relacionada con la obesidad, predicen el riesgo de diabetes tipo 2. Las personas con mayores concentraciones de adiponectina mostraron una menor probabilidad de desarrollar este trastorno metabólico.
Área de la Ciencia:
- Investigación de enfermedades metabólicas.
- Endocrinología Endocrinología.
- Estudios de obesidad estudios de la obesidad.
Sus antecedentes:
- La adiponectina es una hormona proteica secretada por el tejido adiposo.
- Está implicado en la mediación de la resistencia a la insulina asociada con la obesidad.
- Comprender el papel de la adiponectina es crucial para la investigación de enfermedades metabólicas.
Objetivo del estudio:
- Para investigar la asociación entre los niveles de adiponectina y el desarrollo de la diabetes tipo 2.
- Evaluar el valor predictivo de la adiponectina para la diabetes tipo 2 en un estudio longitudinal.
Principales métodos:
- Se realizó un estudio de caso-control dentro de la población india Pima.
- 70 individuos que desarrollaron diabetes tipo 2 (casos) fueron emparejados con 70 controles basados en IMC, edad y sexo.
- Se midieron las concentraciones basales de adiponectina y se compararon entre los casos y los controles.
Principales resultados:
- Las concentraciones basales de adiponectina fueron significativamente más bajas en las personas que más tarde desarrollaron diabetes tipo 2 en comparación con los controles (p = 0,01).
- Los niveles más altos de adiponectina al inicio se asociaron con una menor incidencia de diabetes tipo 2 (IRR 0,63; p=0,02).
Conclusiones:
- La adiponectina puede servir como un biomarcador para predecir el riesgo de diabetes tipo 2.
- Los niveles más bajos de adiponectina se asocian con una mayor probabilidad de desarrollar diabetes tipo 2.
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