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Plasmodium malariae resistente a la cloroquina en el sur de Sumatra, Indonesia
Jason D Maguire1, Iwa W Sumawinata, Sofyan Masbar
1United States Naval Medical Research Unit #2, Jakarta, Indonesia. maguirejd@namru2.med.navy.mil
Lancet (London, England)
|July 13, 2002
Resumen
La resistencia a la cloroquina en Plasmodium malariae está surgiendo. Este estudio en Indonesia encontró evidencia de resistencia clínica a la cloroquina, incluso cuando los niveles de la droga eran adecuados, lo que indica una creciente preocupación por la salud pública.
Área de la Ciencia:
- La medicina tropical es una de ellas.
- Enfermedades infecciosas Las enfermedades infecciosas.
- Parasitología Parasitología.
Sus antecedentes:
- La cloroquina es el tratamiento estándar para las infecciones por Plasmodium malariae en todo el mundo.
- La emergente resistencia a los medicamentos plantea una amenaza significativa para los esfuerzos de control de la malaria.
Objetivo del estudio:
- Evaluar la eficacia in vivo de la cloroquina para el tratamiento de las infecciones por Plasmodium malariae.
- Para investigar la resistencia potencial a la cloroquina en P. malariae en Indonesia.
Principales métodos:
- Estudio prospectivo de 28 días en 28 pacientes con infecciones por P. malariae.
- Monitoreo de la parasitemia y medición de las concentraciones de cloroquina y desetilcloroquina en sangre completa.
Principales resultados:
- Dos pacientes presentaron parasitemia persistente para el día 8.
- Un paciente tenía parasitemia recurrente al día 28.
- Se observaron concentraciones adecuadas de fármaco en pacientes con parasitemia persistente.
Conclusiones:
- La resistencia clínica de Plasmodium malariae a la cloroquina se está produciendo en el sudeste asiático.
- Este hallazgo tiene implicaciones para las estrategias de tratamiento de la malaria en la región.
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