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Mediación de la muerte celular dependiente de la poli (ADP-ribosa) polimerasa-1 por el factor inductor de la

Seong-Woon Yu1, Hongmin Wang, Marc F Poitras

  • 1Department of Neurology and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Science (New York, N.Y.)
|July 13, 2002
PubMed
Resumen

La poli (ADP-ribosa) polimerasa-1 (PARP-1) desencadena la muerte celular programada mediante la señalización de la liberación del factor inductor de la apoptosis (AIF) de las mitocondrias. Esta vía independiente de la caspasa es crucial para la respuesta al daño del ADN y la supervivencia celular.

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