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¿Es la hormona del embarazo relaxina también un péptido vasodilatador secretado por el corazón?
Carol Fisher1, Margaret MacLean, Ian Morecroft
1Department of Medicine and Therapeutics, Institute of Biomedical and Life Sciences, University of Glasgow, Scotland, UK.
Circulation
|July 18, 2002
Resumen
La hormona relaxina secretada por el corazón dilata poderosamente las arterias sistémicas, ayudando potencialmente a la regulación cardiovascular. Este efecto, mediado por el endotelio, no se observó en las arterias pulmonares.
Área de la Ciencia:
- Fisiología cardiovascular fisiología cardiovascular.
- Endocrinología Endocrinología.
Sus antecedentes:
- La hormona relaxina, tradicionalmente relacionada con el embarazo, ahora se sabe que es secretada por el corazón.
- Su papel en la regulación cardiovascular es un área emergente de investigación.
Objetivo del estudio:
- Para investigar los efectos de la relaxina en las pequeñas arterias humanas de resistencia.
- Para comparar la acción de la relaxina en la circulación sistémica frente a la pulmonar.
Principales métodos:
- Las arterias sistémicas y pulmonares humanas se estudiaron utilizando miografía de alambre.
- Se generaron curvas de concentración-respuesta acumuladas para la relaxina y otros vasodilatadores.
- El papel del endotelio fue evaluado mediante su extirpación.
Principales resultados:
- La relaxina causó una vasodilatación significativa en las arterias sistémicas (respuesta máxima 66+/-16%).
- La acción vasodilatadora de la relaxina dependía de la presencia del endotelio.
- La relaxina no demostró ningún efecto vasodilatador significativo en las arterias pulmonares.
Conclusiones:
- La relaxina secretada por el corazón es un potente vasodilatador de las arterias de resistencia sistémica humana.
- La relaxina puede desempeñar un papel en la regulación de la presión arterial sistémica.
- Sus efectos son específicos para la circulación sistémica y requieren un endotelio intacto.
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