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Videos de Conceptos Relacionados

Newman Projections02:06

Newman Projections

Different notations are used to represent the three-dimensional structure of molecules on two-dimensional surfaces. One of the most commonly used representations is the dash-wedge formula. The dashed wedges, solid wedges, and the plane lines indicate the groups situated behind the plane, coming out of the plane, and in the plane, respectively.
The organic molecules rotate across the single bonds leading to numerous temporary three-dimensional structures of varying energy known as conformers.
Polymer Classification: Architecture01:14

Polymer Classification: Architecture

Polymers are classified as linear or branched on the basis of their chain architecture. The polymer chains in linear polymers have a long chain-like structure with minimal to no branching at all. Even if a polymer features large substituent groups on the monomer, which appear as branches to the skeleton, it is not considered a branched polymer. A branched polymer contains secondary polymer chains that arise from the main polymer chain. The branching occurs when the polymer growth shifts from...
Radical Chain-Growth Polymerization: Chain Branching01:17

Radical Chain-Growth Polymerization: Chain Branching

The skeletal structure of polymers synthesized via radical polymerization is always branched. For example, the polymerization of ethylene by radical polymerization results in a low-density grade of polyethylene with a heavily branched skeletal structure. Here, the radical site abstracts hydrogen from the growing chain, and the radical site shifts from the end (a primary carbon center) to anywhere within the growing chain (a secondary carbon center). Consequently, the part of the chain from the...
Anionic Chain-Growth Polymerization: Overview01:20

Anionic Chain-Growth Polymerization: Overview

The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...
Anionic Chain-Growth Polymerization: Mechanism01:04

Anionic Chain-Growth Polymerization: Mechanism

The mechanism for anionic chain-growth polymerization involves initiation, propagation, and termination steps. In the initiation step, a nucleophilic anion, such as butyl lithium, initiates the polymerization process by attacking the π bond of the vinylic monomer. As a result, a carbanion, stabilized by the electron‐withdrawing group, is generated. The resulting carbanion acts as a Michael donor in the propagation step and attacks the second vinylic monomer, which acts as a Michael acceptor.
Types of Step-Growth Polymers: Polyesters01:20

Types of Step-Growth Polymers: Polyesters

The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the polymer...

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Video Experimental Relacionado

Updated: Jul 11, 2026

Grafting Multiwalled Carbon Nanotubes with Polystyrene to Enable Self-Assembly and Anisotropic Patchiness
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Grafting Multiwalled Carbon Nanotubes with Polystyrene to Enable Self-Assembly and Anisotropic Patchiness

Published on: April 1, 2018

Dendrímeros de péptidos basados en hélices de poliprolina.

Laia Crespo1, Glòria Sanclimens, Beatriz Montaner

  • 1Departament de Química Orgànica, Universitat de Barcelona, Martí i Franquès 1, 08028-Barcelona, Spain.

Journal of the American Chemical Society
|July 26, 2002
PubMed
Resumen

Los nuevos dendrímeros peptídicos que utilizan hélices de prolina muestran captación celular y formación de complejos con ciprofloxacina. Estas nuevas poliprolinas ramificadas ofrecen potencial en aplicaciones de administración de fármacos y biomateriales.

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Operation of the Collaborative Composite Manufacturing (CCM) System
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Grafting Multiwalled Carbon Nanotubes with Polystyrene to Enable Self-Assembly and Anisotropic Patchiness
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Área de la Ciencia:

  • La bioquímica es la bioquímica.
  • Ciencia de los materiales Ciencia de los materiales.
  • Química Medicinal La Química Medicinal es el campo de la Química Medicinal.

Sus antecedentes:

  • Los dendrímeros peptídicos son macromoléculas complejas con diversas aplicaciones.
  • Las hélices de poliprolina (PPI y PPII) exhiben propiedades estructurales únicas.
  • La síntesis controlada de estructuras dendríticas es crucial para los materiales funcionales.

Objetivo del estudio:

  • Para sintetizar y caracterizar una nueva familia de dendrímeros peptídicos.
  • Para investigar el comportamiento conformacional de estos dendrímeros.
  • Para evaluar la internalización celular y las propiedades de complejación de fármacos.

Principales métodos:

  • Síntesis de péptidos convergentes en fase sólida.
  • Espectroscopia de dicroísmo circular para el análisis conformacional.
  • Estudios de captación celular utilizando células de riñón de rata.
  • Estudios de complicaciones con ciprofloxacina en el propanol.

Principales resultados:

  • Síntesis exitosa de dendrímeros peptídicos basados en poliprolina y cis-4-amino-L-prolina.
  • Observación de las transiciones conformacionales (PPI a PPII) en las poliprolinas ramificadas.
  • Se ha demostrado la internalización activa de poliprolinas tanto lineales como dendríticas por las células renales.
  • Pruebas preliminares de la formación de complejos de ciprofloxacina con cadenas ramificadas de poliprolina.

Conclusiones:

  • Los nuevos dendrímeros peptídicos exhiben interesantes propiedades conformacionales y absorción celular.
  • Las estructuras ramificadas de poliprolina muestran potencial para interactuar con moléculas pequeñas como los antibióticos.
  • Estos hallazgos sugieren aplicaciones potenciales en sistemas de administración de fármacos y biomateriales.