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La activación de las vías centrales de la melanocortina por la fenfluramina
Lora K Heisler1, Michael A Cowley, Laurence H Tecott
1Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Science (New York, N.Y.)
|July 27, 2002
Resumen
La D-fenfluramina (d-FEN), un fármaco eficaz para la pérdida de peso, fue retirada debido a problemas cardíacos. Una nueva investigación muestra d-FENEN.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Farmacología Farmacología.
- Investigación de la obesidad.
Sus antecedentes:
- La D-fenfluramina (d-FEN) fue un medicamento de pérdida de peso altamente efectivo.
- Su uso clínico se suspendió debido a complicaciones cardíacas en algunos pacientes.
- Comprender el mecanismo del d-FEN podría conducir a fármacos más seguros contra la obesidad.
Objetivo del estudio:
- Para aclarar los mecanismos neurobiológicos detrás de los efectos supresores del apetito de d-FEN.
- Identificar posibles objetivos terapéuticos para nuevos tratamientos de la obesidad.
Principales métodos:
- Estudios de neuroanatomía funcional en roedores.
- Análisis del comportamiento de alimentación.
- Grabaciones de electrofisiología.
Principales resultados:
- La anorexia inducida por D-fenfluramina (d-FEN) se basa en la activación de las vías centrales de la melanocortina.
- Los modelos de roedores demostraron un claro vínculo entre el d-FEN y la activación del sistema de melanocortina.
Conclusiones:
- Las vías de la melanocortina son cruciales para los efectos anoréxicos del d-FEN.
- Dirigirse a las vías de la melanocortina aguas abajo puede dar lugar a medicamentos contra la obesidad más seguros y más selectivos.
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