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Videos de Conceptos Relacionados

Adhesion01:14

Adhesion

44.5K
Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow...
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Frequency-dependent Selection01:21

Frequency-dependent Selection

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When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
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Drug Dependence01:17

Drug Dependence

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Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
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Contact-dependent Signaling01:19

Contact-dependent Signaling

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Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
In animal cells, gap junctions are formed...
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Cell Adhesion in Plants01:14

Cell Adhesion in Plants

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Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose,...
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Bacterial Transformation01:33

Bacterial Transformation

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In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
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Updated: Feb 10, 2026

In Vitro and In Vivo Model to Study Bacterial Adhesion to the Vessel Wall Under Flow Conditions
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In Vitro and In Vivo Model to Study Bacterial Adhesion to the Vessel Wall Under Flow Conditions

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Bailando con el anfitrión; adhesión bacteriana dependiente del flujo.

Ralph R Isberg1, Penelope Barnes

  • 1Howard Hughes Medical Institute, Boston, MA 02111, USA. ralph.isberg@tufts.edu

Cell
|August 2, 2002
PubMed
Resumen
Este resumen es generado por máquina.

La adhesión bacteriana a las células huésped es crucial para la colonización. Ciertos pili, mejorados por el estrés de cizallamiento, mejoran la fijación bacteriana a las superficies del huésped como el epitelio.

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Introducing Shear Stress in the Study of Bacterial Adhesion
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Last Updated: Feb 10, 2026

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Introducing Shear Stress in the Study of Bacterial Adhesion
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Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells
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Área de la Ciencia:

  • Microbiología Microbiología.
  • Biología celular Biología celular.
  • La biofísica es la biofísica.

Sus antecedentes:

  • La colonización bacteriana de huéspedes eucariotas requiere una unión directa a las células huésped.
  • La adhesión a menudo está mediada por lectinas en pili en bacterias entéricas.
  • La adhesión mediada por pili puede ser influenciada por fuerzas mecánicas como la tensión de cizallamiento.

Objetivo del estudio:

  • Para investigar el papel de la tensión de corte en la adhesión bacteriana.
  • Para entender el mecanismo de la adhesión pili mediada por lectina.

Principales métodos:

  • Utilizando técnicas biofísicas para estudiar las interacciones pili-célula huésped.
  • Simulación de las condiciones de estrés de cizallamiento fisiológico in vitro.

Principales resultados:

  • Se demostró que los pili específicos exhiben una mayor adherencia bajo tensión de corte.
  • Identificó la función de la lectina como crítica para la fijación dependiente del cizallamiento.
  • Mostró la importancia de las fuerzas mecánicas en la colonización bacteriana.

Conclusiones:

  • El estrés de cizallamiento mejora significativamente la adhesión bacteriana mediada por píldoras específicas.
  • Los pili mediados por lectina son clave para que las bacterias entéricas establezcan nichos en las superficies del huésped bajo condiciones de flujo.