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Determining Basal Energy Expenditure and the Capacity of Thermogenic Adipocytes to Expend Energy in Obese Mice
Published on: November 11, 2021
La señalización betaAR requerida para la termogénesis inducida por la dieta y la resistencia a la obesidad
Eric S Bachman1, Harveen Dhillon, Chen-Yu Zhang
1Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA.
Science (New York, N.Y.)
|August 6, 2002
Resumen
Los receptores beta-adrenérgicos (betaAR) son cruciales para prevenir la obesidad. Los ratones que carecían de ARB beta mostraron un fracaso en la termogénesis inducida por la dieta, lo que condujo a una obesidad masiva cuando se alimentaron con una dieta alta en grasas.
Área de la Ciencia:
- Fisiología Fisiología Fisiología.
- El metabolismo es el metabolismo.
- Investigación de la obesidad.
Sus antecedentes:
- Se cree que el cerebro detecta el consumo excesivo de calorías y activa la termogénesis para prevenir la obesidad.
- El sistema nervioso simpático, a través de los receptores beta-adrenérgicos (betaAR), es una vía eferente potencial para este mecanismo homeostático.
Objetivo del estudio:
- Investigar la necesidad de los receptores beta-adrenérgicos (betaAR) en la termogénesis inducida por la dieta y la prevención de la obesidad.
- Determinar el papel del sistema nervioso simpático en la mediación de la respuesta metabólica a la ingesta calórica.
Principales métodos:
- Generación de ratones que carecen de los tres betaAR conocidos (ratones sin beta).
- Comparación de la tasa metabólica y el desarrollo de la obesidad entre ratones sin beta y ratones de tipo salvaje en dietas de Chow y dietas altas en grasas.
Principales resultados:
- Los ratones sin beta exhibieron una tasa metabólica reducida y una ligera obesidad en una dieta estándar.
- En una dieta alta en grasas, los ratones sin beta desarrollaron obesidad severa, a diferencia de los controles de tipo salvaje.
- Esta obesidad masiva en ratones sin beta se atribuyó a un fracaso completo de la termogénesis inducida por la dieta.
Conclusiones:
- Los receptores beta-adrenérgicos (betaAR) son esenciales para la termogénesis inducida por la dieta.
- La vía del sistema nervioso simpático mediada por betaAR es crítica para la defensa contra la obesidad inducida por la dieta.
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