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Molécula de adhesión intercelular soluble-1, molécula de adhesión vascular soluble-1, y el desarrollo de enfermedad
Aruna D Pradhan1, Nader Rifai, Paul M Ridker
1Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass 02115-1204, USA.
Circulation
|August 15, 2002
Resumen
Los niveles elevados de molécula de adhesión intercelular soluble-1 (sICAM-1) predicen el desarrollo de la enfermedad arterial periférica (EAP) en hombres sanos. Este hallazgo pone de relieve sICAM-1 como un biomarcador potencial para el riesgo temprano de aterosclerosis sistémica.
Área de la Ciencia:
- Medicina Cardiovascular La medicina cardiovascular es una especialidad de la salud.
- Los biomarcadores también son biomarcadores.
- Investigación de la aterosclerosis Investigación de la aterosclerosis.
Sus antecedentes:
- Las moléculas de adhesión celular solubles están vinculadas a eventos coronarios.
- La asociación con la aterosclerosis sistémica temprana es incierta.
Objetivo del estudio:
- Investigar la relación entre los niveles de molécula de adhesión intercelular soluble-1 (sICAM-1) y de molécula de adhesión celular vascular soluble-1 (sVCAM-1) y el desarrollo de la enfermedad arterial periférica sintomática (EAP).
Principales métodos:
- Estudio prospectivo y anidado de casos y controles de 14.916 hombres de mediana edad.
- Se evaluaron los niveles basales de sICAM-1 y sVCAM-1.
- Se siguió a los participantes durante 9 años para el desarrollo de la PAD.
- Análisis estadísticos ajustados por factores de riesgo.
Principales resultados:
- Se observaron niveles basales más altos de sICAM-1 en hombres que desarrollaron EAP (P=0,005).
- El aumento de sICAM-1 se asoció significativamente con un mayor riesgo de EAP (OR 3.5, P=0.008) después de los ajustes.
- Los niveles de sVCAM-1 no se asociaron con el desarrollo de la EAP.
Conclusiones:
- La elevación de sICAM-1 es un predictor independiente de la aterosclerosis acelerada.
- sICAM-1 puede servir como un biomarcador para el riesgo de EAP en hombres sanos.
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