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Los mastocitos: un vínculo celular entre los autoanticuerpos y la artritis inflamatoria

David M Lee¹, Daniel S Friend, Michael F Gurish

¹Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Science (New York, N.Y.)

|September 7, 2002

Resumen

Los mastocitos son cruciales en el desarrollo de la artritis erosiva en ratones K/BxN. Estas células actúan como un vínculo entre los autoanticuerpos y las señales inflamatorias, impulsando la inflamación articular.

Área de la Ciencia:

Inmunología Inmunología.
Reumatología Reumatología.
Biología celular Biología celular.

Sus antecedentes:

La artritis erosiva en ratones K/BxN involucra autoanticuerpos, el complemento y los receptores Fc.
Los agentes celulares específicos que responden a estos mediadores inflamatorios siguen sin ser identificados.

Objetivo del estudio:

Para identificar las poblaciones celulares que median la artritis inflamatoria en ratones K/BxN.
Para aclarar el papel de los mastocitos en la patogénesis de la artritis inflamatoria.

Principales métodos:

Se utilizaron cepas de ratón con deficiencia de mastocitos (W/Wv y Sl/Sld).
Evaluación de la susceptibilidad a la inflamación articular en estas cepas.
Investigó el efecto del injerto de mastocitos en la restauración de la susceptibilidad.

Principales resultados:

Los ratones con deficiencia de mastocitos (W/Wv y Sl/Sld) mostraron resistencia a la inflamación articular.
El injerto de mastocitos en ratones W/Wv restauró la susceptibilidad al desarrollo de la artritis.

Conclusiones:

Los mastocitos son componentes celulares esenciales en el desarrollo de la artritis inflamatoria en ratones K/BxN.
Los mastocitos pueden servir como un enlace celular crítico que conecta los autoanticuerpos y los mediadores solubles a las células efectoras en la patogénesis de la artritis.

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