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Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Adición oxidativa de agua y alcoholes alifáticos por IrCl ((trialquilfosfina) ((3))
1Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel. oferblum@umich.edu
Journal of the American Chemical Society
|September 19, 2002
Resumen
Los complejos de iridio se someten a adición oxidativa con alcoholes y agua, formando productos hidrido-alcoxo. Las tasas de reacción varían según la estructura del alcohol y la polaridad del disolvente, lo que sugiere un mecanismo de ataque nucleófilo.
Área de la Ciencia:
- Química organometálica Química orgánica de los metales.
- Química Inorgánica La Química Inorgánica es la química inorgánica.
- Mecanismos de reacción Mecanismos de reacción
Sus antecedentes:
- Los complejos de iridio son cruciales en la catálisis.
- Comprender la adición oxidativa es clave para los ciclos catalíticos.
- La adición de alcohol alifático y agua a los complejos de iridio no se entiende completamente.
Objetivo del estudio:
- Para investigar la adición oxidativa de alcoholes alifáticos y agua a complejos de iridio.
- Para dilucidar el mecanismo de reacción y la cinética.
- Para caracterizar los productos resultantes.
Principales métodos:
- Reacciones de adición oxidativa en el benceno y el THF.
- Estudios cinéticos para determinar las velocidades de reacción y las dependencias.
- Caracterización cristalográfica del complejo hidroxo.
Principales resultados:
- Formación de los productos cis-hidrido-alcoxo (mer-cis-HIr o Cl o PMe 3)).
- La velocidad de reacción está influenciada por la estructura del alcohol y la polaridad del disolvente.
- Los datos cinéticos sugieren que una especie de iridio de 16 electrones sufre adición oxidativa a través de un ataque nucleófilo.
Conclusiones:
- La reacción procede a través de un ataque nucleófilo de un solo paso en el protón O-H.
- El ligando de cloruro influye en la estabilidad del estado de transición y la estereoquímica.
- La agregación del disolvente protótico puede ocurrir en el estado de transición.
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