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La ulceración anal asociada al nicorandil está asociada con la nicorandil
Angus Watson1, Ous Al-Ozairi, Andy Fraser
1Department of Surgery, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK. a.j.watson@abdn.ac.uk
Lancet (London, England)
|September 21, 2002
Resumen
El nicorandil, un vasodilatador para la angina de pecho, puede causar úlceras anales. Cinco pacientes experimentaron estas úlceras, que se curaron después de suspender la medicación, lo que sugiere un vínculo potencial.
Área de la Ciencia:
- Gastroenterología y Gastroenterología.
- Cardiología Cardiología.
- Farmacología Farmacología.
Sus antecedentes:
- Nicorandil es un medicamento vasodilatador comúnmente prescrito para la angina de pecho.
- Informes anteriores han relacionado el uso de nicorandil con ulceración oral y estomatitis.
- Estos efectos secundarios orales generalmente se resuelven al suspender el medicamento.
Objetivo del estudio:
- Para investigar una posible asociación entre el nicorandil y la ulceración anal.
- Para describir las características clínicas e histológicas de las úlceras anales en pacientes que usan nicorandil.
Principales métodos:
- Se revisó una serie de casos de cinco pacientes que presentaban una ulceración anal no específica.
- Todos los pacientes de la serie estaban recibiendo nicorandil para el manejo de la enfermedad cardíaca isquémica.
- Se analizaron los datos clínicos y los hallazgos histológicos de las úlceras anales.
Principales resultados:
- Cinco pacientes que recibieron nicorandil para la enfermedad cardíaca isquémica desarrollaron ulceración anal no específica.
- El examen histológico reveló hallazgos similares en todos los casos reportados.
- La curación de la úlcera anal se observó en todos los pacientes después del cese de la terapia con nicorandil.
Conclusiones:
- Los hallazgos sugieren que el nicorandil puede ser una causa poco reconocida de la ulceración anal.
- Se necesitan más investigaciones para confirmar el papel etiológico del nicorandil en el desarrollo de úlceras anales.
- Los médicos deben considerar el nicorandil como una causa potencial en pacientes que presentan úlceras anales.
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