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Interruptor metálico para la formación de amiloides: información sobre la estructura del núcleo

David M Morgan1, Jijun Dong, Jaby Jacob

  • 1Center for the Analysis of SupraMolecular Self-assemblies, Department of Chemistry, Emory University, 1521 Pierce Drive, Atlanta, Georgia 30322, USA.

Journal of the American Chemical Society
|October 24, 2002
PubMed
Resumen

Los iones de zinc (Zn2+) aceleran la formación de amiloides al aumentar la velocidad de nucleación de los péptidos Abeta (10-21). Sin embargo, el Zn2+ no afecta a la propagación de las fibras ni a su morfología, lo que indica que desempeña un papel específico en la agregación amiloide en etapas tempranas.

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