Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Chemical Reactions01:19

Chemical Reactions

A chemical reaction is a process by which the bonds in the atoms of substances are rearranged to generate new substances. Matter cannot be created or destroyed in a chemical reaction—the same type and number of atoms that make up the reactants are still present in the products. Merely, the rearrangement of chemical bonds produces new compounds.
Chemical Reactions Rearrange Atoms into New Substances
A chemical reaction takes starting materials—the reactants—and changes them into different...
SN1 Reaction: Mechanism02:25

SN1 Reaction: Mechanism

Kinetic studies of ionization of a tertiary halide in a protic solvent suggest that only the substrate participates in the rate-determining step (slow step). The nucleophile is involved only after the slowest step. The SN1 reaction takes place in a multiple-step mechanism. 
Firstly, the haloalkane ionizes to generate a carbocation intermediate and a halide ion. This heterolytic cleavage is highly endothermic with large activation energy. The ionization of the substrate, facilitated by a polar...
Radical Reactivity: Overview01:11

Radical Reactivity: Overview

Radicals, the highly reactive species, gain stability by undergoing three different reactions. The first reaction involves a radical-radical coupling, in which a radical combines with another radical, forming a spin‐paired molecule. The second reaction is between a radical and a spin‐paired molecule, generating a new radical and a new spin‐paired molecule. The third reaction is radical decomposition in a unimolecular reaction, forming a new radical and a spin‐paired molecule. These three...
Chain Reactions01:29

Chain Reactions

Chain reactions involve highly reactive transient species, such as atoms or free radicals, as intermediates. These intermediates facilitate rapid reactions over an extended period. The process includes a series of steps: a reactive intermediate is consumed, reactants are converted to products, and the intermediate is regenerated. This cycle enables continuous repetition, amplifying the production of products with a small amount of intermediate. Chain reactions often utilize free radicals as...
Fast Reactions01:27

Fast Reactions

Fast reactions occurring in times shorter than the time needed to mix reactants pose a unique challenge for investigation. In a liquid-phase continuous-flow system, reactants A and B are swiftly pushed into the mixing chamber, where mixing occurs within 1 ms. The reaction mixture then flows through an observation tube, and one measures light absorption to determine species concentrations at various points of the tube. This method is most appropriate when relatively large volumes of reactants...
Production of Pharmaceuticals01:30

Production of Pharmaceuticals

Industrial insulin production uses genetically engineered E. coli expressing a proinsulin gene controlled by a tryptophan promoter and containing a methionine linker for later cleavage. The cells also carry ampicillin resistance for selective growth. Seed cultures are stored at −80 °C and production begins by thawing a small amount to inoculate starter cultures, which are progressively scaled to a 50,000-L bioreactor. In the bioreactor, E. coli grow in nutrient-rich media under sterile, tightly...

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Exploring the Co-Crystallization Landscape of One-Dimensional Coordination Polymers Using a Molecular Electrostatic Potential-Driven Approach.

Crystal growth & design·2024
Same author

Competition between chalcogen and halogen bonding assessed through isostructural species.

Acta crystallographica. Section C, Structural chemistry·2022
Same author

Evaluating structure-property relationship in a new family of mechanically flexible co-crystals.

Chemical communications (Cambridge, England)·2022
Same author

Influence of Multiple Binding Sites on the Supramolecular Assembly of <i>N</i>-[(3-pyridinylamino) Thioxomethyl] Carbamates.

Molecules (Basel, Switzerland)·2022
Same author

The Balance between Hydrogen Bonds, Halogen Bonds, and Chalcogen Bonds in the Crystal Structures of a Series of 1,3,4-Chalcogenadiazoles.

Molecules (Basel, Switzerland)·2021
Same author

Intermolecular binding preferences of haloethynyl halogen-bond donors as a function of molecular electrostatic potentials in a family of <i>N</i>-(pyridin-2-yl)amides.

Organic & biomolecular chemistry·2021

Video Experimental Relacionado

Updated: Jul 11, 2026

Utilization of Stop-flow Micro-tubing Reactors for the Development of Organic Transformations
13:09

Utilization of Stop-flow Micro-tubing Reactors for the Development of Organic Transformations

Published on: January 4, 2018

Una reacción supramolecular de alto rendimiento.

Christer B Aakeröy1, Alicia M Beatty, Brian A Helfrich

  • 1Department of Chemistry, Kansas State University, Manhattan, Kansas, USA. aakeroy@ksu.edu

Journal of the American Chemical Society
|November 28, 2002
PubMed
Resumen

La isonicotinamida forma consistentes "supermoléculas" enlazadas con hidrógeno con ácidos carboxílicos. Este reactivo supramolecular crea de manera confiable ensamblajes moleculares discretos, incluso con ácidos dicarboxílicos, produciendo estructuras predecibles.

Más Videos Relacionados

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
07:36

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy

Published on: November 9, 2019

A Scalable Balz-Schiemann Reaction Protocol in a Continuous Flow Reactor
05:21

A Scalable Balz-Schiemann Reaction Protocol in a Continuous Flow Reactor

Published on: February 10, 2023

Videos de Experimentos Relacionados

Last Updated: Jul 11, 2026

Utilization of Stop-flow Micro-tubing Reactors for the Development of Organic Transformations
13:09

Utilization of Stop-flow Micro-tubing Reactors for the Development of Organic Transformations

Published on: January 4, 2018

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
07:36

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy

Published on: November 9, 2019

A Scalable Balz-Schiemann Reaction Protocol in a Continuous Flow Reactor
05:21

A Scalable Balz-Schiemann Reaction Protocol in a Continuous Flow Reactor

Published on: February 10, 2023

Área de la Ciencia:

  • Ingeniería de Cristal Ingeniería de Cristal.
  • Química supramolecular de las moléculas.
  • Ciencia de los materiales Ciencia de los materiales.

Sus antecedentes:

  • El enlace de hidrógeno juega un papel crucial en el autoensamblaje molecular.
  • La isonicotinamida es una molécula versátil con funcionalidades de amida y piridina.
  • Los ácidos carboxílicos son bloques de construcción comunes en la química supramolecular.

Objetivo del estudio:

  • Para investigar las preferencias de enlace de hidrógeno de la iso-nicotinamida con varios ácidos carboxílicos.
  • Para caracterizar las estructuras supramoleculares resultantes formadas.
  • Para evaluar la fiabilidad de la iso-nicotinamida como un reactivo supramolecular.

Principales métodos:

  • Determinación de la estructura cristalina de rayos X de doce cocristales.
  • Análisis de patrones de enlaces de hidrógeno y síntonos supramoleculares.
  • Comparación de estructuras formadas con ácidos mono y dicarboxílicos.

Principales resultados:

  • Se observó un patrón consistente de preferencias de enlaces de hidrógeno.
  • "Supermoléculas" discretas formadas entre la iso-nicotinamida y los ácidos monocarboxílicos.
  • Las interacciones ácido carboxílico-piridina y amida-amida fueron las sintones dominantes.
  • Los ácidos dicarboxílicos llevaron a ensamblajes infinitos o complejos hexaméricos.
  • Se logró una conectividad bien definida y robusta en todos los casos.

Conclusiones:

  • La isonicotinamida actúa como un reactivo supramolecular confiable.
  • La formación predecible de supermoléculas es posible con los ácidos carboxílicos.
  • Los patrones de enlace de hidrógeno observados son robustos en diversas funcionalidades químicas.