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La guanina de la tercera hebra del triplex C.G*G sirve como una trampa para agujeros eficaz

Chikara Dohno1, Kazuhiko Nakatani, Isao Saito

  • 1Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, CREST, Japan Science and Technology Corporation (JST), Kyoto 606-8501, Japan.

Journal of the American Chemical Society
|December 6, 2002
PubMed
Resumen

La escisión del ADN oxidativo se dirige selectivamente a las repeticiones de guanina (G) en la tercera hebra del ADN de triple hélice. Esto ocurre debido a una oxidación más fácil y una rápida desprotonación de G en la tercera hebra, lo que lleva a daños preferenciales.

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