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Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
Published on: June 3, 2016
Las fuerzas del fluido intracárdico son un factor epigenético esencial para la cardiogénesis embrionaria
Jay R Hove1, Reinhard W Köster, Arian S Forouhar
1Options of Bioengineering and Aeronautics, Division of Engineering & Applied Science, California Institute of Technology, Pasadena, California 91125, USA. jhove@caltech.edu
Nature
|January 10, 2003
Resumen
Los patrones de flujo sanguíneo son cruciales para el desarrollo del corazón. Las altas fuerzas de corte en los embriones de pez cebra causaron una formación anormal del corazón, destacando la hemodinámica.
Área de la Ciencia:
- Biología del desarrollo Biología del desarrollo.
- Fisiología cardiovascular fisiología cardiovascular.
- La biofísica es la biofísica.
Sus antecedentes:
- Se supone que los patrones de flujo sanguíneo influyen en la morfogénesis cardíaca.
- Las células endoteliales in vitro responden a las fuerzas de flujo alterando la estructura citoesquelética y la expresión génica.
Objetivo del estudio:
- Para analizar cuantitativamente in vivo las fuerzas del flujo intracardiaco en el desarrollo de embriones de pez cebra.
- Para vincular los hallazgos in vitro sobre las respuestas celulares inducidas por el flujo al corazón en desarrollo intacto.
- Para investigar el papel de la hemodinámica intracardiaca en la cardiogénesis embrionaria.
Principales métodos:
- Imágenes cuantitativas in vivo del flujo sanguíneo intracardiaco en embriones de pez cebra.
- Predicción de las fuerzas inducidas por el flujo basado en patrones de flujo observados.
- Oclusión in vivo de las vías de entrada o salida cardíacas para interrumpir el flujo sanguíneo normal.
Principales resultados:
- Se identificó un flujo vorticoso de alto corte en etapas críticas del desarrollo del corazón del pez cebra.
- Las fuerzas de flujo intracárdico pronosticadas son significativamente más altas de lo esperado para los sistemas a microescala.
- La oclusión del flujo condujo a defectos cardíacos, incluida una tercera cámara anormal, un bucle deteriorado y una formación de válvula defectuosa.
Conclusiones:
- La hemodinámica intracardiaca, caracterizada por altas fuerzas de cizallamiento, es crítica para el desarrollo normal del corazón embrionario.
- La interrupción de los patrones normales de flujo sanguíneo in vivo da como resultado defectos congénitos similares al corazón.
- Las fuerzas hemodinámicas actúan como un factor epigenético clave que influye en la cardiogénesis.
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