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Las parejas toxina-antitoxina en las bacterias: ¿asesinas o reguladoras del estrés?
Christopher S Hayes1, Robert T Sauer
1Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Cell
|January 16, 2003
Resumen
Los sistemas plásmidos de toxina-antitoxina tienen homólogos cromosómicos. La toxina RelE de E. coli divide el ARNm en el sitio ribosomal A, actuando como un regulador de estrés durante el hambre de aminoácidos.
Área de la Ciencia:
- Microbiología Microbiología.
- Biología Molecular Biología Molecular
- Genética bacteriana Genética bacteriana.
Sus antecedentes:
- Los sistemas de toxina-antitoxina codificados en plásmido son cruciales para el mantenimiento del plásmido al eliminar las células que pierden el plásmido.
- Estos sistemas poseen homólogos cromosómicos en varios dominios procariotas, incluidas las eubacterias y las arqueas.
- Los mecanismos moleculares precisos y las funciones fisiológicas de estos homólogos cromosómicos no están completamente aclarados.
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