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La taurina y la vitamina C modifican la disfunción monocítica y endotelial en fumadores jóvenes
F M Fennessy1, D S Moneley, J H Wang
1Department of Surgery, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.
Circulation
|January 29, 2003
Resumen
La suplementación con taurina y vitamina C mejoró la función endotelial en fumadores jóvenes al modular las interacciones monocito-endotelial. La taurina mostró un impacto beneficioso más significativo en la salud endotelial macrovascular.
Área de la Ciencia:
- Investigación Cardiovascular Investigación Cardiovascular Investigación Cardiovascular Investigación Cardiovascular
- Biología endotelial Biología endotelial.
- Ciencias de la Nutrición Ciencias de la Nutrición
Sus antecedentes:
- Las interacciones monocito-endotelial contribuyen a la disfunción endotelial en condiciones como el tabaquismo crónico.
- La taurina y la vitamina C poseen propiedades protectoras endoteliales conocidas contra el estrés inflamatorio.
Objetivo del estudio:
- Investigar la eficacia de la taurina y la vitamina C en la restauración de la función endotelial en fumadores jóvenes.
- Para determinar si estos suplementos modifican las interacciones monocito-endotelial.
Principales métodos:
- Se evaluó la vasodilatación en vivo dependiente del endotelio utilizando ultrasonografía dúplex.
- Evaluación de las interacciones monocito-endotelial in vitro utilizando células endotelial de la vena umbilical humana (HUVEC) y el medio monocito-condicionado (MCM).
Principales resultados:
- Los fumadores jóvenes exhibieron un deterioro de la vasodilatación endotelial dependiente en comparación con los no fumadores.
- La suplementación con taurina (1,5 g/d) y vitamina C (2 g/d) atenuó este deterioro.
- El MCM derivado del fumador redujo el óxido nítrico y aumentó la liberación de endotelina-1 de las HUVEC; el tratamiento con taurina revirtió estos efectos a través de la regulación al alza de la sintetasa de óxido nítrico endotelial.
Conclusiones:
- La suplementación con taurina tiene un impacto positivo en la función endotelial macrovascular.
- Se recomienda una mayor investigación sobre los efectos de la taurina en la función endotelial en los estados dislipidémicos.
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