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Nephrotic Syndrome I : Introduction

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El consumo de alcohol y la concentración plasmática de proteína C reactiva

Michelle A Albert¹, Robert J Glynn, Paul M Ridker

¹Center for Cardiovascular Disease Prevention, Division of Cardiovascular Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass 02115, USA. maalbert@partners.org

|January 29, 2003

Resumen

La ingesta moderada de alcohol está relacionada con niveles más bajos de proteína C reactiva (CRP), un marcador de inflamación y riesgo cardiovascular. Esta asociación sugiere que el alcohol puede reducir la mortalidad cardiovascular en parte a través de efectos antiinflamatorios.

Área de la Ciencia:

Cardiología Cardiología.
Ciencias de la Nutrición Ciencias de la Nutrición
Investigación de la inflamación Investigación de la inflamación.

Sus antecedentes:

El consumo moderado de alcohol está relacionado con una reducción de la mortalidad cardiovascular.
Los datos sobre la relación entre la proteína C reactiva (CRP) y la ingesta de alcohol son limitados.

Objetivo del estudio:

Investigar la asociación entre el consumo de alcohol y los niveles de PCR.
Para explorar los posibles mecanismos antiinflamatorios de los beneficios cardiovasculares del alcohol.

Principales métodos:

Encuesta transversal y análisis longitudinal de 1732 hombres y 1101 mujeres.
Categorización de la ingesta de alcohol en cinco niveles, desde nada de alcohol hasta >=2 bebidas diarias.
Análisis multivariado que controla los factores de riesgo cardiovasculares tradicionales.

Principales resultados:

La ingesta moderada de alcohol (1-7 bebidas por semana) se asoció con niveles significativamente más bajos de PCR en comparación con la ingesta ocasional o no.
Esta relación inversa entre el consumo de alcohol y la PCR fue consistente en todos los subgrupos, incluidos hombres, mujeres, fumadores y personas con o sin enfermedad cardiovascular.
La asociación se mantuvo significativa después de ajustar los factores de riesgo cardiovascular y fue independiente de los efectos del alcohol en los niveles de lípidos.

Conclusiones:

El consumo moderado de alcohol se asocia con concentraciones más bajas de PCR, lo que sugiere un efecto antiinflamatorio.
El alcohol puede contribuir a reducir la mortalidad cardiovascular a través de mecanismos más allá de la modificación de los lípidos.
Se justifica una mayor investigación sobre las vías antiinflamatorias del alcohol.

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