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Localización específica del endosoma y función del activador del ARF GNOM

Juan S Bonifacino¹, Catherine L Jackson

¹Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

|January 30, 2003

Resumen

El activador de ARF de Arabidopsis GNOM controla el tráfico polarizado del portador de eflujo de auxina PIN1 a la membrana plasmática basal al localizarse en los endosomas. Este estudio revela la regulación espacial de la activación de ARF en el tráfico de células vegetales.

Área de la Ciencia:

Biología celular vegetal Biología celular vegetal
La ciencia molecular de las plantas.
El tráfico de teléfonos celulares.

Sus antecedentes:

Las GTPasas del factor de ribosilación de ADP (ARF) son reguladores cruciales de las vías de tráfico intracelular, incluidas las vías secretoras y vacuolares / lisosomal.
Los mecanismos de control espacial precisos que rigen la activación de ARF siguen siendo en gran medida no caracterizados, lo que dificulta una comprensión completa de sus diversas funciones celulares.

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