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COMT val158met genotipo afecta las respuestas de los neurotransmisores mu-opioides a un estresante del dolor
Jon-Kar Zubieta1, Mary M Heitzeg, Yolanda R Smith
1Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109-0720, USA. zubieta@umich.edu
Science (New York, N.Y.)
|February 22, 2003
Resumen
Las variaciones genéticas en la catecol-O-metiltransferasa (COMT) influyen en cómo los individuos experimentan el dolor. El polimorfismo COMT val158met afecta la percepción del dolor y las respuestas emocionales al estrés.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Genética La genética.
- Investigación del dolor Investigación del dolor.
Sus antecedentes:
- Las respuestas al dolor y al estrés implican interacciones cerebrales y neuroquímicas complejas.
- Las diferencias individuales en la percepción del dolor son significativas.
- Las catecolaminas juegan un papel crucial en la modulación del estrés y el dolor.
Objetivo del estudio:
- Investigar el impacto de un polimorfismo genético común en la catecol-O-metiltransferasa (COMT) en las respuestas humanas al dolor.
- Comprender cómo las variaciones del gen COMT modulan los sistemas neuroquímicos involucrados en la percepción del dolor.
Principales métodos:
- Estudió el polimorfismo de la catecol-O-metiltransferasa (COMT) val158met en los participantes humanos.
- Evalúa la actividad del sistema mu-opioide regional durante el dolor sostenido.
- Se midieron las calificaciones de dolor sensorial y afectivo y el estado afectivo interno.
Principales resultados:
- Los individuos con el genotipo homocigótico COMT met158 exhibieron respuestas reducidas del sistema mu-opioide al dolor.
- Estos individuos informaron mayores calificaciones de dolor sensorial y afectivo y un estado de ánimo más negativo.
- Se observaron efectos opuestos en los homocigotos val158, lo que indica una clara influencia genética.
Conclusiones:
- El polimorfismo COMT val158met influye significativamente en la experiencia humana del dolor.
- Esta variación genética puede explicar las diferencias interindividuales en la adaptación y respuesta al dolor y el estrés.
- Dirigirse a las vías COMT podría ofrecer nuevas vías para las estrategias de manejo del dolor.
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