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Vacunación con BCG y riesgo de atopia
Tyra G Krause1, Anders Hviid, Anders Koch
1Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen S, Denmark. tgv@ssi.dk
JAMA
|February 25, 2003
Resumen
La vacunación con BCG en los bebés no parece reducir el riesgo de desarrollar atopia. Este estudio no encontró diferencias significativas en la prevalencia de atopia entre los niños vacunados y no vacunados.
Área de la Ciencia:
- Inmunología Inmunología.
- La pediatría es la medicina de los niños.
- Salud Pública La salud pública.
Sus antecedentes:
- Se sugiere la vacunación Bacille Calmette-Guérin (BCG) para proteger contra las enfermedades alérgicas.
- La vacunación BCG era de rutina en Groenlandia hasta 1990, y su retirada provocó una investigación sobre posibles aumentos en la atopia infantil.
Objetivo del estudio:
- Investigar la asociación entre la vacunación BCG y el desarrollo de atopia en niños.
- Examinar si la edad a la que se administra la vacuna BCG influye en el riesgo de atopia.
Principales métodos:
- Se realizó un estudio transversal entre 1686 escolares de entre 8 y 16 años en Groenlandia.
- Se midieron los niveles séricos de IgE contra los alérgenos inhalados comunes para definir la atopia.
- Se recopilaron datos sobre el estado de vacunación BCG y la edad en la vacunación.
Principales resultados:
- No se observó diferencia significativa en el riesgo de atopia entre los niños vacunados con BCG y los no vacunados (OR, 1.03; IC del 95%, 0.72-1.48).
- La edad a la que se administró la vacuna BCG no mostró asociación con el riesgo de desarrollar atopia (P = .17).
Conclusiones:
- La vacunación infantil con BCG no se asocia con un riesgo reducido de desarrollo de atopia.
- Los hallazgos sugieren que la vacunación BCG no confiere protección contra la atopia en esta población.
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