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Updated: Jun 23, 2026

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La pérdida de la activación de TGF-beta mediada por integrina alfa (v) beta6 causa enfisema dependiente de Mmp12

David G Morris1, Xiaozhu Huang, Naftali Kaminski

  • 1Lung Biology Center, Department of Medicine, San Francisco General Hospital, San Francisco, California 94143, USA.

Nature
|March 14, 2003
PubMed
Resumen

La pérdida de integrina alfa ((v) beta6 afecta la activación del factor de crecimiento transformador-beta (TGF-beta), lo que lleva al enfisema relacionado con la edad en ratones. La restauración de la señalización de TGF-beta o el bloqueo de Mmp12 previene esta enfermedad pulmonar.

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