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Updated: Jul 3, 2026
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Novel Approach for Simultaneous Recording of Renal Sympathetic Nerve Activity and Blood Pressure with Intravenous Infusion in Conscious, Unrestrained Mice.
Published on: February 14, 2018
El aumento de la actividad nerviosa simpática en la insuficiencia cardíaca y la apnea central del sueño se debe a la
Darren Mansfield1, David M Kaye, Hanspeter Brunner La Rocca
1Department of Respiratory Medicine and Monash University, Alfred Hospital, Melbourne, Victoria, Australia.
Circulation
|March 19, 2003
Resumen
Los pacientes con insuficiencia cardíaca congestiva con apnea central del sueño tienen una mayor actividad nerviosa simpática y presión arterial pulmonar. Estas elevaciones están relacionadas con la gravedad de la insuficiencia cardíaca, no con la gravedad de la apnea del sueño en sí.
Área de la Ciencia:
- Cardiología Cardiología.
- Medicina del sueño Medicina del sueño.
- Fisiología Fisiología Fisiología.
Sus antecedentes:
- La insuficiencia cardíaca congestiva con apnea central del sueño (CHF-CSA) está relacionada con el aumento de la norepinefrina (NE) y la presión arterial pulmonar (PAP).
- La relación entre la CSA, la actividad del nervio simpático y la gravedad de la CHF sigue sin estar clara.
Objetivo del estudio:
- Para investigar la actividad del nervio simpático en pacientes con CHF con apnea central del sueño (CHF-CSA), apnea obstructiva del sueño (CHF-OSA) y respiración normal (CHF-N).
- Para correlacionar el derrame de NE y la hemodinámica cardíaca con la gravedad de la apnea en pacientes con CHF.
Principales métodos:
- Se midió el derrame de norepinefrina (NE) corporal total y cardíaca utilizando dilución de radioisótopos en 55 pacientes con FCH.
- Los pacientes se clasificaron en grupos CHF-N (19), CHF-OSA (15) y CHF-CSA (21) basados en la polisomnografía.
- Se evaluó la hemodinámica cardíaca, incluida la presión arterial pulmonar media (PAP), a través del cateterismo cardíaco derecho.
Principales resultados:
- Los pacientes con CHF-CSA exhibieron un derrame corporal total y cardíaco significativamente mayor en comparación con los grupos de CHF-N y CHF-OSA.
- Los pacientes con CHF-CSA también mostraron un PAP promedio significativamente más alto.
- Después de controlar la gravedad de la ECH, no se encontraron diferencias significativas en la cinética de la ECH entre los grupos.
- El PAP promedio se correlacionó de manera independiente con el derrame de NE en el cuerpo total y en el corazón.
Conclusiones:
- La actividad elevada del nervio simpático en CHF-CSA se asocia con la gravedad de la insuficiencia cardíaca, no con la gravedad de la apnea.
- La presión arterial pulmonar promedio es un determinante clave de la activación simpática en pacientes con insuficiencia cardíaca congestiva.
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