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Sinovitis crónica y HLA B27 en pacientes con hemofilia grave
Kanjaksha Ghosh1, Umapathy Shankarkumar, Shrimati Shetty
1Institute of Immunohaematology, Floor 13, New Building, KEM Hospital Campus, Parel, 400 012, Mumbai, India.
Lancet (London, England)
|March 22, 2003
Resumen
Existe una fuerte asociación entre el HLA B27 y la sinovitis crónica en pacientes con hemofilia severa en la India. La detección de HLA B27 podría ayudar a prevenir esta complicación.
Área de la Ciencia:
- Inmunogenética La inmunogenética.
- Reumatología Reumatología.
- Hematología Hematología.
Sus antecedentes:
- La sinovitis crónica es una complicación de la hemofilia grave, particularmente en la India.
- La espondilitis anquilosante, que comparte características con la sinovitis crónica, está asociada con el HLA B27.
Objetivo del estudio:
- Investigar la asociación entre el HLA B27 y la sinovitis crónica en pacientes indios con hemofilia grave.
Principales métodos:
- Un estudio en el que participaron 473 pacientes con hemofilia grave (33 con sinovitis crónica) y 1175 controles sanos.
- Se utilizaron técnicas serológicas estándar y el ensayo de banda de línea inversa para la prueba de HLA B27.
Principales resultados:
- El 64% de los pacientes con hemofilia con sinovitis crónica dieron positivo para HLA B27.
- Se observó una prevalencia significativamente mayor de HLA B27 en pacientes con sinovitis crónica en comparación con aquellos sin y controles sanos (OR 31.6, p<0.0001).
Conclusiones:
- Existe una fuerte asociación entre el HLA B27 y la sinovitis crónica en pacientes indios con hemofilia grave.
- La detección de HLA B27 en esta población puede facilitar el tratamiento temprano y las estrategias de prevención de la sinovitis crónica.
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