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Updated: Jul 9, 2026

Pooled shRNA Screen for Reactivation of MeCP2 on the Inactive X Chromosome
11:15

Pooled shRNA Screen for Reactivation of MeCP2 on the Inactive X Chromosome

Published on: March 2, 2018

Papel de la metilación de la histona H3 y la lisina 27 en la inactivación de X

Kathrin Plath1, Jia Fang, Susanna K Mlynarczyk-Evans

  • 1Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143, USA.

Science (New York, N.Y.)
|March 22, 2003
PubMed
Resumen

El complejo de proteínas Eed y Ezh2 del grupo policombo (PcG) se recluta en el cromosoma X inactivo (Xi) durante la iniciación de la inactivación X tanto en células embrionarias como extraembrionarias. Este reclutamiento, mediado por el ARN Xist, conduce a la metilación de la histona H3 y la lisina 27, pero es insuficiente para silenciar los genes.

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