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An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
Published on: March 30, 2018
Esclerosis múltiple y el virus de Epstein-Barr
Lynn I Levin1, Kassandra L Munger, Mark V Rubertone
1Division of Preventive Medicine, Walter Reed Army Institute of Research, Washington, DC, USA.
JAMA
|April 4, 2003
Resumen
Los anticuerpos del virus de Epstein-Barr (EBV), particularmente las IgG contra el antígeno de la cápside viral (VCA) y el complejo EBNA, están significativamente elevados años antes de la aparición de la esclerosis múltiple (EM). Esto sugiere un fuerte vínculo entre la infección por EBV y el desarrollo de EM.
Área de la Ciencia:
- Neurología Neurología.
- Inmunología Inmunología.
- Enfermedades infecciosas Enfermedades infecciosas.
Sus antecedentes:
- La infección por el virus de Epstein-Barr (EBV) es un factor de riesgo conocido para la esclerosis múltiple (EM).
- La relación temporal precisa entre la infección por EBV y la aparición de EM no ha quedado clara.
- Comprender este vínculo es crucial para las posibles estrategias de prevención de la EM.
Objetivo del estudio:
- Investigar la asociación temporal entre los niveles de anticuerpos del virus Epstein-Barr (EBV) y el posterior desarrollo de la esclerosis múltiple (EM).
- Para determinar si los anticuerpos elevados del EBV preceden al inicio clínico de la EM.
Principales métodos:
- Se realizó un estudio de casos y controles anidados utilizando una gran cohorte de personal militar de los Estados Unidos (más de 3 millones).
- Las muestras de sangre recolectadas entre 1988-2000 fueron analizadas en busca de anticuerpos contra los antígenos del EBV (VCA, complejo EBNA, antígenos tempranos) y el citomegalovirus.
- Los casos fueron individuos diagnosticados con EM, con controles emparejados por edad, sexo, raza / etnia y fechas de recolección de muestras.
Principales resultados:
- Los anticuerpos IgG elevados contra el antígeno de la cápside viral EBV (VCA) y el complejo EBNA fueron fuertes predictores del riesgo de EM.
- El riesgo de EM aumentó monotónicamente con los títulos de anticuerpos, con riesgos relativos tan altos como 33.9 para el complejo EBNA.
- Se observaron asociaciones significativas incluso en muestras recolectadas 5 o más años antes del diagnóstico de EM.
- No se encontró asociación entre los anticuerpos del citomegalovirus y el riesgo de EM.
Conclusiones:
- Los hallazgos sugieren fuertemente una relación causal entre la infección por el virus de Epstein-Barr y el desarrollo de la esclerosis múltiple.
- Los anticuerpos del EBV sirven como biomarcadores tempranos potenciales para el riesgo de EM.
- Se justifica una mayor investigación sobre los mecanismos que vinculan la patogénesis del EBV y la EM.
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