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Conservación del peso sináptico total a través de la depresión sináptica equilibrada y la potenciación
1Center for Molecular & Behavioral Neuroscience, Rutgers State University, 197 University Avenue, Newark, New Jersey 07102, USA.
Nature
|April 4, 2003
Resumen
La plasticidad neural permite que cambie la fuerza de la sinapsis, pero puede causar inestabilidad. Un mecanismo homeostático en las neuronas de la amígdala estabiliza el peso sináptico total al equilibrar la potenciación y la depresión.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- La plasticidad sináptica.
- Estabilidad Neural La estabilidad neuronal.
Sus antecedentes:
- La memoria se basa en cambios de fuerza sináptica dependientes de la actividad.
- La potenciación sináptica y la depresión pueden conducir a la inestabilidad de la red en los modelos.
- Se necesita un mecanismo homeostático para equilibrar la plasticidad y la estabilidad.
Objetivo del estudio:
- Investigar un mecanismo homeostático que reconcilia la plasticidad y la estabilidad en las redes neuronales.
- Explorar cómo las modificaciones sinápticas en un sitio afectan a otros dentro de una neurona.
Principales métodos:
- Estudió las neuronas intercaladas en la amígdala.
- Examinó la potenciación dependiente de la actividad y la depresión de los insumos glutamatérgicos.
- Utilizó diálisis intracelular con medicamentos que bloquean la liberación de Ca2+.
Principales resultados:
- La potenciación / depresión de una entrada causó cambios opuestos en otras entradas.
- El peso sináptico total se mantuvo estable a pesar de las intensidades de entrada relativas modificadas.
- La plasticidad heterosináptica inversa fue bloqueada al inhibir la liberación de Ca2+.
Conclusiones:
- La plasticidad heterosináptica inversa en las neuronas intercaladas de la amígdala estabiliza el peso sináptico total.
- Este mecanismo compensa la potenciación homo-sináptica a largo plazo y la depresión.
- Proporciona evidencia biológica para conciliar la plasticidad neuronal y la estabilidad.
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