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El poliovirus tipo 1 en existencias de trabajo de rinovirus humanos tipificados
Marc Davies1, Christine Bruce, Kevin Bewley
1National Collection of Pathogenic Viruses, Centre for Applied Microbiology and Research, Salisbury, UK.
Lancet (London, England)
|April 11, 2003
Resumen
Las existencias de poliovirus de laboratorio representan un riesgo de reintroducción. El poliovirus tipo 1 se encontró en las existencias de rinovirus humanos, lo que pone de relieve la necesidad de un cribado urgente y la destrucción de los materiales contaminados.
Área de la Ciencia:
- Virología Virología.
- Epidemiología de las enfermedades infecciosas.
- Salud Pública La salud pública.
Sus antecedentes:
- Los esfuerzos mundiales de erradicación han reducido significativamente la circulación del poliovirus silvestre.
- Las vías potenciales de reintroducción incluyen existencias de laboratorio y muestras de pacientes/ambientales.
- La identificación errónea de las poblaciones virales puede representar un riesgo oculto.
Objetivo del estudio:
- Investigar el riesgo de reintroducción del poliovirus a partir de existencias de laboratorio sin poliovirus.
- Para evaluar la prevalencia de la contaminación por poliovirus en colecciones virales mal identificadas.
- Hacer hincapié en la importancia de los protocolos de detección rigurosos en los laboratorios de virología.
Principales métodos:
- Análisis de "acciones de trabajo" identificadas inicialmente como otros virus.
- Detección molecular y serotipo de agentes virales dentro de estas poblaciones.
- Evaluación del riesgo de materiales contaminados.
Principales resultados:
- El poliovirus tipo 1 se detectó en al menos cuatro poblaciones de laboratorio identificadas erróneamente como serotipos de rinovirus humanos.
- Esto indica un riesgo significativo de contaminación cruzada o identificación errónea en los repositorios virales.
- Los hallazgos subrayan las vulnerabilidades en la gestión actual de las poblaciones virales.
Conclusiones:
- Es fundamental una evaluación urgente de la presencia de poliovirus en poblaciones virales aparentemente bien caracterizadas.
- El cribado necesario y la destrucción de materiales donde el riesgo supera el beneficio son primordiales.
- Se requiere una mayor vigilancia para evitar la reintroducción inadvertida del poliovirus.
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