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De saber a controlar: un camino desde la genómica a las drogas utilizando sondas de pequeñas moléculas
Robert L Strausberg1, Stuart L Schreiber
1Cancer Genomics Office, National Cancer Institute, 31 Center Drive, Bethesda, MD 20892, USA. RLS@nih.gov
Science (New York, N.Y.)
|April 12, 2003
Resumen
El Instituto Nacional del Cáncer es el Instituto Nacional del Cáncer.
Área de la Ciencia:
- Genética química y genética química.
- Biología molecular La biología molecular.
- La bioinformática es la bioinformática.
Sus antecedentes:
- El Instituto Nacional del Cáncer (NCI) apoya la investigación en genética química.
- Las sondas moleculares pequeñas son herramientas esenciales en genética química.
- Comprender la función del producto génico es crucial en estados normales y de enfermedad.
Objetivo del estudio:
- Promover el desarrollo y la utilización de la genética química.
- Para crear recursos para discernir las funciones del producto genético.
- Para cerrar la brecha entre el descubrimiento genómico y el desarrollo de fármacos.
Principales métodos:
- Desarrollo de sondas moleculares pequeñas para la modulación de proteínas.
- Establecimiento de ChemBank, un conjunto de herramientas informáticas y bases de datos.
- Facilitar el acceso científico global a los recursos de genética química.
Principales resultados:
- Creación de recursos para ayudar a comprender las funciones de los productos genéticos.
- Establecimiento de ChemBank para apoyar la investigación en genética química.
- Proporcionar un camino desde los datos genómicos hasta los posibles objetivos terapéuticos.
Conclusiones:
- La iniciativa del NCI fomenta la investigación en genética química.
- ChemBank sirve como un recurso vital para la comunidad científica.
- Esta iniciativa es fundamental para el avance de las tuberías de descubrimiento de fármacos.
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