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La selección de equilibrio en el gen de la proteína priónica es consistente con las epidemias prehistóricas kurulike
Simon Mead1, Michael P H Stumpf, Jerome Whitfield
1Medical Research Council Prion Unit, and Department of Neurodegenerative Disease, Institute of Neurology, University College, Queen Square, London WC1N 3BG, UK.
Science (New York, N.Y.)
|April 12, 2003
Resumen
Los sobrevivientes de la enfermedad de Kuru muestran resistencia genética debido a la heterocigosidad del gen de la proteína priónica (PRNP). Esto sugiere que la selección de equilibrio influyó en la evolución humana al favorecer a los heterocigotos PRNP 129.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Genética La genética.
- La Antropología Antropología Antropología.
Sus antecedentes:
- Kuru es una enfermedad priónica fatal endémica del pueblo Fore de Papúa Nueva Guinea, transmitida históricamente a través del endocanibalismo.
- Se sabe que el polimorfismo del gen de la proteína priónica humana (PRNP) 129 influye en la susceptibilidad a las enfermedades priónicas.
- Estudios anteriores indicaron que la heterocigosidad de PRNP 129 confiere una protección relativa contra las enfermedades priónicas.
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