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Los cables largos que unen los centros redox a las columnas vertebrales del polímero mejoran el transporte de
Fei Mao1, Nicolas Mano, Adam Heller
1TheraSense Inc., 1360 South Loop Road, Alameda, California 94502, USA.
Journal of the American Chemical Society
|April 17, 2003
Resumen
Este estudio introduce un nuevo hidrogel redox con una difusión de electrones significativamente mejorada. Las amarras largas permiten una transferencia eficiente de electrones de las enzimas, mejorando el rendimiento de la electrooxidación de la glucosa.
Área de la Ciencia:
- La electroquímica es electroquímica.
- La ciencia de los polímeros es la ciencia de los polímeros.
- Los biomateriales son biomateriales.
Sus antecedentes:
- Los hidrogeles redox son cruciales para las aplicaciones electroquímicas.
- La mejora de la difusión de electrones y la interacción de las enzimas es clave para la eficiencia.
- Los centros redox basados en osmio ofrecen propiedades electroquímicas sintonizables.
Objetivo del estudio:
- Desarrollar un hidrogel redox con un mejorado coeficiente de difusión aparente de electrones (D(app)).
- Para investigar el efecto de la longitud del cable en la eficiencia de la transferencia de electrones.
- Para mejorar la electrooxidación de la glucosa utilizando hidrogeles modificados por enzimas.
Principales métodos:
- Síntesis de un polímero redox reticulado con brazos espaciadores largos.
- Enlace de los complejos N,N'-biimidazol Os(2+/3+) tris-dialquilados a la columna vertebral del polímero.
- Caracterización electroquímica del hidrogel, incluyendo las mediciones de D ((app) y densidad de corriente.
Principales resultados:
- Se logró un coeficiente de difusión aparente de electrones (Dapp) de (5.8 +/- 0.5) x 10-6 cm-2 s-1), un orden de magnitud más alto que los hidrogeles anteriores.
- Se ha demostrado una eficiente recolección de electrones de la glucosa oxidasa debido a los lazos largos y flexibles.
- Se observó electrooxidación eficiente de glucosa a -0.36 V frente a Ag/AgCl con una densidad de corriente límite de 1.15 mA cm(-2) a -0.1 V frente a Ag/AgCl.
Conclusiones:
- Atar los centros redox a través de largos brazos espaciadores mejora significativamente la difusión de electrones en los hidrogeles.
- Los nuevos tethers complejos y flexibles Os(2+/3+) permiten una electrocatálisis altamente eficiente mediada por enzimas.
- Este hidrogel redox avanzado muestra un gran potencial para los biosensores electroquímicos y las células de biocombustible.
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