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La activación de la integrina alfaIIbbeta3 por la modulación de las asociaciones de la hélice transmembrana

Renhao Li1, Neal Mitra, Holly Gratkowski

  • 1Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Science (New York, N.Y.)
|May 6, 2003
PubMed
Resumen

Las mutaciones de la hélice transmembrana de la integrina promueven la activación y agrupación de la integrina alfaIIbbeta3. Las asociaciones homoméricas de dominios transmembranares impulsan la actividad de las integrinas, ofreciendo una base estructural para la activación y el agrupamiento.

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