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La baja actividad de la paraoxonasa predice eventos coronarios en el Estudio Prospectivo de Caerphilly
Bharti Mackness1, Paul Durrington, Patrick McElduff
1University Department of Medicine, Manchester Royal Infirmary, University of Manchester, Oxford Rd, Manchester M13 9WL, UK.
Circulation
|May 21, 2003
Resumen
La baja actividad de la paraoxonasa sérica (PON1) es un factor de riesgo independiente para los eventos de enfermedad coronaria (CHD, por sus siglas en inglés). Este hallazgo pone de relieve la PON1.
Área de la Ciencia:
- Investigación cardiovascular Investigación cardiovascular Investigación cardiovascular Investigación cardiovascular Investigación cardiovascular
- La bioquímica es la bioquímica.
- Epidemiología La epidemiología.
Sus antecedentes:
- Estudios previos sugirieron que la paraoxonasa (PON1) puede prevenir la aterosclerosis.
- Faltaban pruebas prospectivas de esta hipótesis.
Objetivo del estudio:
- Investigar prospectivamente la asociación entre la actividad PON1 sérica y el riesgo de enfermedad coronaria (CHD).
- Para determinar si la actividad de PON1 es un predictor independiente de eventos cardiovasculares.
Principales métodos:
- Se analizó la cohorte del Estudio Prospectivo de Caerphilly de 1353 hombres (de entre 49 y 65 años).
- Se midió la actividad PON1 sérica y se correlacionó con los eventos incidentes de ECC durante 15 años.
- Se realizaron ajustes estadísticos para los factores de riesgo tradicionales de ECC.
Principales resultados:
- Los hombres con menor actividad sérica de PON1 tenían un riesgo significativamente mayor de eventos coronarios (20% menos actividad, P=0,039).
- Se observó una relación inversa graduada entre los quintiles de actividad PON1 y el riesgo de ECC.
- La actividad de PON1 fue un predictor significativo, especialmente en hombres con enfermedad preexistente o múltiples factores de riesgo.
Conclusiones:
- La reducción de la actividad PON1 sérica es un factor de riesgo independiente para eventos coronarios.
- La actividad de PON1 es particularmente predictiva en individuos de alto riesgo.
- Estos hallazgos apoyan el papel de la PON1 en la salud cardiovascular.
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