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Updated: Jul 8, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

Diferentes orientaciones de unión para el mismo agonista en receptores homólogos: una cerradura y llave o una simple

Ting-Wei Mu1, Henry A Lester, Dennis A Dougherty

  • 1Division of Chemistry and Chemical Engineering and Division of Biology, California Institute of Technology, Pasadena, California 91125, USA.

Journal of the American Chemical Society
|June 5, 2003
PubMed
Resumen

Los investigadores estudiaron el receptor de serotonina MOD-1 en el C. elegans. Descubrieron que utiliza un residuo de triptófano diferente al del receptor 5-HT3, lo que sugiere una reorganización del ligando al unirse.

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