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A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
Published on: January 24, 2016
Asociación entre la tuberculosis y un sitio polimórfico de unión NFkappaB en el gen gamma del interferón
Manda Rossouw1, Hendrik J Nel, Graham S Cooke
1MRC Centre for Molecular and Cellular Biology and Department of Medical Biochemistry, Faculty of Health Sciences, Stellenbosch University, 7505, Tygerberg, South Africa.
Lancet (London, England)
|June 6, 2003
Resumen
Una variación genética específica en el interferón gamma (IFNG) está relacionada con la susceptibilidad a la tuberculosis. Este factor genético influye en los mecanismos de defensa del huésped, impactando potencialmente en el desarrollo de la tuberculosis.
Área de la Ciencia:
- Inmunogenética La inmunogenética.
- Enfermedades infecciosas Enfermedades infecciosas.
- Biología Molecular Biología Molecular
Sus antecedentes:
- El interferón gamma (IFNG) juega un papel crítico en la defensa del huésped contra diversas infecciones.
- Las variaciones genéticas dentro del gen IFNG pueden influir en la susceptibilidad a enfermedades infecciosas como la tuberculosis.
Objetivo del estudio:
- Investigar la asociación entre un polimorfismo específico en el gen gamma del interferón (IFNG) y la susceptibilidad a la tuberculosis.
- Determinar si la variabilidad genética en IFNG afecta el riesgo de desarrollar tuberculosis.
Principales métodos:
- Un estudio de casos y controles en el que participaron 313 casos de tuberculosis y una población sudafricana.
- Un estudio basado en familias que utiliza la prueba de desequilibrio de transmisión en 131 familias.
- Análisis del polimorfismo +874A-->T dentro del gen IFNG.
Principales resultados:
- Se encontró una asociación significativa entre el polimorfismo +874A-->T en IFNG y la tuberculosis en la población sudafricana (p=0,0055).
- Esta asociación se replicó con éxito en el estudio basado en la familia (p = 0,005).
- El factor de transcripción NFkappaB se une preferentemente al alelo +874T, que es más común en los controles.
Conclusiones:
- Las variaciones genéticamente determinadas en la expresión gamma del interferón, influenciadas por el polimorfismo +874A-->T, pueden ser importantes en la patogénesis de la tuberculosis.
- Los hallazgos sugieren un papel para la variabilidad genética de IFNG en la susceptibilidad a la tuberculosis.
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